A biotechnology company based in San Francisco (USA) develops drugs aimed at extending the health and life of dogs. On Tuesday, November 28, it was announced that there had been an “important milestone in cooperation with the FDA” (US Food and Drug Administration). The breakthrough concerns the conditional approval of LOY-001 injections, which are intended to delay aging in large dogs.
USA. A drug that extends the life of dogs is getting closer to approval. “There was no regulatory pathway for a life-extending drug.”
The company announced that it has completed one of the formalities needed to obtain approval for the use of the drug to extend the life of large dogs. “Because there was no established regulatory pathway for a life-extending drug, we had to design from scratch a scientifically sound and logistically feasible way to demonstrate the anti-aging drug’s effectiveness (ed.). This process took over four years, resulting in a more than 2,300-page technical section currently approved by the FDA,” he said.
Loyal’s drug still needs to pass approval in the safety and manufacturing sections, among others. If the procedures are successful, veterinarians will be able to prescribe LOY-001 to prolong the life of large dogs. “Our interventional studies with LOY-001 showed that the drug improves clinically important parameters of aging,” it said.
Bigger dogs live shorter? A hormone and selective breeding are responsible for this
Scientists have pointed out that large breeds may live shorter than small dogs. Some of this disparity is due to the process of selective breeding, which has caused genetic problems in many breeds. Breeding for the size of the animals has resulted in very elevated levels of the hormone IGF-1, which drives cell growth. This, in turn, causes the dog to age faster and develop health problems faster. “LOY-001 extends lifespan in part by reducing IGF-1 to levels seen in smaller breed dogs,” Loyal reported.
Source: Gazeta
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