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They identify genetic markers for the improvement of cancer treatments

They identify genetic markers for the improvement of cancer treatments

A study led by the Spanish Institute of Oncological and Molecular Medicine of Asturias (Imoma) identified genetic markers to improve cancer treatments. cancer that prove the usefulness of liquid biopsy in patients oncology treated with radiotherapy.

This research was published in the scientific journal British Journal of Cancer on December 22, Imoma reported on Tuesday.

Liquid biopsy is a state-of-the-art genetic test that obtains information on tumors non-invasively, from a patient’s blood sample and without the need to biopsy the tumor.

The study, whose first author is Guadalupe Álvarez Cifuentes – technical manager of R&D of the Imoma laboratory – consisted of analyzing liquid biopsies obtained from fifty patients treated in the Radiotherapy Service of the same center.

More than 800 liquid biopsies were obtained and processed before, during and after the radiotherapy treatment of all the patients and complementary genetic analyzes were also carried out, both of the tumor itself and of the patients, which allowed a better interpretation of the results of the liquid biopsy.

The team of researchers, led by doctors Rubén Cabanillas and Juan Cadiñanos, concluded that liquid biopsy makes it possible to identify possible personalized therapies for cancer treatment (approved or under development) in more than half of the patients analyzed.

The study also demonstrated that the combination of liquid biopsy with complementary analysis of the tumor and the patient allowed real-time monitoring of tumor behavior during and after treatment.

Likewise, he points out that the work reveals that, even before treatment, liquid biopsy can be used to predict which of the treated patients are more likely to be cured.

In addition, he points out that liquid biopsies performed after treatment can also be used to predict whether the disease will progress before this becomes evident through diagnostic images (PET-CT, resonance, etc.).

It also highlights that the complementary analyzes made it possible to detect that 6 percent of the patients had a hereditary predisposition to the development of cancer, which would not have been detected if these people had not been subject to the genomic analyzes carried out in this project.

(With information from EFE)

Source: Gestion

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