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Scientists in France, Spain and Mexico have found that the SARS-CoV-2 coronavirus can awaken dormant retroviral sequences in the human genome, which leads to the development of serious chronic diseases. This is reported in an article published in the medRxiv preprint repository.
The researchers found that the coronavirus S-protein can activate the human endogenous retrovirus (HERV) gene in blood cells, which encodes the ENV protein involved in the assembly of viral envelopes. Expression of the ENV protein in T-lymphocytes has been previously associated with severe respiratory distress syndrome in patients with SARS-CoV-2, but the mechanism remains unknown.
During the experiment, scientists added recombinant S-protein to the culture of peripheral blood mononuclear cells of patients with SARS-CoV-2. As a result, they observed the activation of the gene encoding ENV in 20-30 percent of people infected with COVID-19. This likely indicates a genetic predisposition among those infected to ENV activation and respiratory distress syndrome.
More than one percent of the human genome is known to be remnants of the HERV-W retrovirus, which is more than the protein-coding sequences. Some of these residues, when activated, can lead to various diseases, including multiple sclerosis.
Source: Rosbalt
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